1. Itoh T, Omori Y, Seino M, Hirose K, Date F, Ono Y, Mizukami Y, Aoki S, Ishida M, Mizuma M, Morikawa T, Higuchi R, Honda G, Okamura Y, Kinoshita K, Unno M, Furukawa T. Gene rearrangement and expression of PRKACA and PRKACB governs morpho-biology of pancreatobiliary oncocytic neoplasms. Modern Pathology. 2023. In press.
  2. Koizumi A, Tamura Y, Yoshida R, Mori C, Ono Y, Tanino M, Mizukami Y, Sasaki T. Two Cases of SMARCA4-Deficient Non-small Cell Lung Cancer (NSCLC) with Improved Performance Status (PS) after Treatment with Immune Checkpoint Inhibitors (ICIs). The Cureus Journal of Medical Science. 2023. 15(4): e37656.
  3. Kitagawa S, Ichihara S, Omori Y, Maeda C, Ono Y, Tahara M, Furukawa T, Muraoka S, Miyakawa H. Branch-duct Intraductal Papillary Mucinous Neoplasm with Rapidly Developing Intracystic Xanthogranulomatous Nodules. Intern Med. 2023.
  4. Dote S, Shiwaku E, Kohno E, Fujii R, Mashimo K, Morimoto N, Yoshino M, Odaira N, Ikesue H, Hirabatake M, Takahashi K, Takahashi M, Takagi M, Nishiuma S, Ito K, Shimato A, Itakura S, Takahashi Y, Negoro Y, Shigemori M, Watanabe H, Hayasaka D, Nakao M, Tasaka M, Goto E, Kataoka N, Yokomizo A, Kobayashi A, Nakata Y, Miyake M, Hayashi Y, Yamamoto Y, Hirata T, Azuma K, Makihara K, Fukui R, Tokutome A, Yagisawa K, Honda S, Meguro Y, Suzuki S, Yamaguchi D, Miyata H, Kobayashi Y, Investigators I. Impact of prior bevacizumab therapy on the incidence of ramucirumab-induced proteinuria in colorectal cancer: a multi-institutional cohort study. Int J Clin Oncol. 2023:1-9.
  5. Koizumi A, Tamura Y, Yoshida R, Mori C, Ono Y, Tanino M, Mizukami Y, Sasaki T. Two Cases of SMARCA4-Deficient Non-small Cell Lung Cancer (NSCLC) with Improved Performance Status (PS) after Treatment with Immune Checkpoint Inhibitors (ICIs). The Cureus Journal of Medical Science. 2023. 15(4): e37656
  6. Yuzawa, S, Michizuka T, Kakisaka ROno Y, Hayashi M, Takahara M, Katada A, Mizukami Y, Tanino M. Low-grade papillary Schneiderian carcinoma with TP53 mutation: a case report and review of the literature. Diagnostic Pathology. 2023.18(1):44
  1. Hirose K, Omori Y, Ono Y, Mizukami Y, Kaneko Y, Maruyama T, Ohtani H, Furukawa T. Molecular comparison of concurrent components of high-grade dysplasia, adenocarcinoma, and sarcomatoid carcinoma in a case of sarcomatoid carcinoma of the gallbladder. Virchows Archiv. 2023. in Press.
  2. Maeda C, Ono Y, Hayashi A, Takahashi K, Taniue K, Kakisaka R, Mori M, Ishii T, Sato H, Okada T, Kawabata H, Goto T, Tamamura N, Omori Y, Takahashi K, Katanuma A, Karasaki H, Andrew S. L, Mizukami Y. Multiplex digital PCR assay to detect multiple KRAS and GNAS mutations associated with pancreatic carcinogenesis from minimal specimen amounts. Journal of Molecular Diagnostics. 2023. in Press.
  3. Kokumai T, Omori Y, Ishida M, Ohtsuka H, Mizuma M, Nakmagawa K, Maeda C, Ono Y, Mizukami Y, Miura S, Kume K, Masamune A, Morikawa T, Unno M, Furukawa T. GATA6 and CK5 Stratify the Survival of Patients With Pancreatic Cancer Undergoing Neoadjuvant Chemotherapy. Modern Pathology. 2023; 36(5):100102. Online ahead of print.
  4. Omori Y, Ono Y, Morikawa T, Motoi F, Higuchi R, Yamamoto M, Hayakawa Y, Karasaki H, Mizukami Y, Unno M, Furukawa T. Serine/Threonine Kinase 11 Plays a Canonical Role in Malignant Progression of KRAS-mutant and GNAS-wild-type Intraductal Papillary Mucinous Neoplasms of the Pancreas. Ann Surg. 2023;277: e384-e395.
  5. Murakami Y, Tanabe H, Ono Y, Sugiyama Y, Kobayashi Y, Kunogi T, Sasaki T, Takahashi K, Ando K, Ueno N, Kashima S, Yuzawa S, Moriichi K, Mizukami Y, Fujiya M, Okumura T. Local recurrence after successful endoscopic submucosal dissection for rectal mucinous mucosal adenocarcinoma: A case report. World Journal of Gastrointestinal Oncology. 2023. 15(1): 186-194.
  6. Ono M,Ono Y, Nakamura T, Tsuchikawa T, Kuraya T, Kuwabara S, Nakanishi Y, Asano T, Matsui A, Tanaka K, Ebihara Y, Kurashima Y, Noji T, Murakami S, Shichinohe T, Mitsuhashi T, Omori Y, Furukawa T, Taniue K, Suzuki M, Sugitani A, Karasaki H, Mizukami Y, Hirano S. Predictors of Long-Term Survival in Pancreatic Ductal Adenocarcinoma after Pancreatectomy: TP53 and SMAD4 Mutation Scoring in Combination with CA19-9. Ann Surg Oncol. 2022. Doi:10.1245/s10434-022-11630-0. Online ahead of print.
  1. Kono T, Maejima T, Ono Y, Itoh T, Furukawa S, Nishiyama M, Yamamoto M, Sugitani A, Karasaki H, Mizukami Y, Maemoto A. Distinct effects of TU-100 (daikenchuto) on long-lasting dysbiosis in the small intestine in patients with colorectal cancer and inflammatory bowel disease. Gene. 2022:146266.
  2. Taniue K, Tanu T, Shimoura Y, Mitsutomi S, Han H, Kakisaka ROno Y, Tamamura N, Takahashi K, Wada Y, Mizukami Y, Akimitsu N. RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival. International Journal of Molecular Sciences. 2022;23(1):496.
  3. Kawabata H, Ono Y, Tamamura N, Oyama K, Ueda J, Sato H, Takahashi K, Taniue K, Okada T, Fujibayashi S, Hayashi A, Goto T, Enomoto K, Konishi H, Fujiya M, Miyakawa K, Tanino M, Nishikawa Y, Koga D, Watanabe T, Maeda C, Karasaki H, Liss AS, Mizukami Y, Okumura T. Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway. J Gastroenterol. 2022. Online ahead of print.
  4. Ishii T, Shitara K. Trastuzumab deruxtecan and other HER2-targeting agents for the treatment of HER2-positive gastric cancerExpert Rev Anticancer Ther.  2021 Nov;21(11):1193-1201.
  5. Suemitsu Y, Ono Y, Mizukami Y, Ye J, Yamakawa K, Takamoto T, Nakano-Narusawa Y, Mukai Y, Manabu T, Nakazawa A, Mino-Kenudson M, Kumasaka T, Matsuda Y. A Case of Adult Pancreatoblastoma with Novel APC Mutation and Genetic Heterogeneity.  Frontiers in Oncology. 2021.
  6. Wang L, Maejima T, Fukahori S, Nishihara S, Yoshikawa D, Kono T. Bowel obstruction and perforation secondary to barbed suture after minimally invasive inguinal hernia repair: report of two cases and literature review. Surg Case Rep. 2021;7(1):161.
  7. Sato H, Liss AS, Mizukami Y. Large-duct pattern invasive adenocarcinoma of the pancreas-a variant mimicking pancreatic cystic neoplasms: A minireview. World J Gastroenterol. 2021;27(23):3262-78.
  8. Higashijima J, Kono T, Shimada M, Kashihara H, Takasu C, Nishi M, Tokunaga T, Sugitani A, Yoshikawa K. Intestinal hypoperfusion in patients with Crohn's disease revealed by intraoperative indocyanine green fluorescence imaging. Ann Med Surg. 2021;66:102402.
  9. Liu Y, Xin B, Yamamoto M, Goto M, Ooshio T, Kamikokura Y, Tanaka H, Meng L, Okada Y, Mizukami Y, Nishikawa Y. Generation of combined hepatocellular-cholangiocarcinoma through transdifferentiation and dedifferentiation in p53-knockout mice. Cancer Sci. 2021.
  10. Wang L, Maejima T, Fukahori S, Shun K, Yoshikawa D, Kono T. Laparoscopic surgical treatment for hydrocele of canal of Nuck: A case report and literature review. Surg Case Rep. 2021;7(1):121.
  11. Sato K, Tsukada N, Inamura J, Komatsu S, Sato K, Yamamoto M, Shindo M, Moriichi K, Mizukami Y, Fujiya M, Torimoto Y, Okumura T. Successful Treatment of Myeloid Sarcoma in an Elderly Patient with Myelodysplastic Syndrome with Reduced-Dose Azacitidine. Case Rep Hematol. 2021;2021:6640597.
  12. Toyonaga H, Mizukami Y, Katanuma A. Ampullary tumor with a rare etiology: A new lesion in the residual ampulla following curative resection of the perihilar cholangiocarcinoma. Gastroenterology. 2021.
  13. Omori Y, Ono Y, Morikawa T, Motoi F, Higuchi R, Yamamoto M, Hayakawa Y, Karasaki H, Mizukami Y, Unno M, Furukawa T. Serine/Threonine Kinase 11 Plays a Canonical Role in Malignant Progression of KRAS-mutant and GNAS-wild-type Intraductal Papillary Mucinous Neoplasms of the Pancreas. Ann Surg. 2021;Publish Ahead of Print.
  14. Yamamoto M, Shindo M, Sumi C, Igarashi S, Saito T, Tsukada N, Toki Y, Hatayama M, Inamura J, Sato K, Mizukami Y, Torimoto Y, Okumura T. Acquired hemophilia A associated with Epstein-Barr-virus-associated T/natural killer-cell lymphoproliferative disease: A case report. Medicine. 2021;100(16):e25518.
  15. Okazaki S, Sasaki T, Yasuda S, Abe M, Yoshida N, Yoshida R, Ishibashi K, Minami Y, Okumura S, Chiba S, Takei H, Hayashi R, Nagato T, Kobayashi H, Sugitani A, Ono Y, Mizukami Y, Kitada M, Ohsaki Y. The feasibility of circulating tumor DNA analysis as a marker of recurrence in triple-negative breast cancer. Oncol Lett. 2021;21(5):420.
  16. Kobayashi T, Omori Y, Ono Y, Karasaki H, Mizukami Y, Makino N, Motoi F, Unno M, Ueno Y, Furukawa T. Pathways for the development of multiple epithelial types of intraductal papillary mucinous neoplasm of the pancreas. J Gastroenterol. 2021;56(6):581-92.
  17. Tanabe H, Mizukami Y, Takei H, Tamamura N, Omura Y, Kobayashi Y, Murakami Y, Kunogi T, Sasaki T, Takahashi K, Ando K, Ueno N, Kashima S, Yuzawa S, Hasegawa K, Sumi Y, Tanino M, Fujiya M, Okumura T. Clinicopathological characteristics of Epstein-Barr virus and microsatellite instability subtypes of early gastric neoplasms classified by the Japanese and the World Health Organization criteria. J Pathol Clin Res. 2021;7(4):397-409.
  18. Sato H, Goto T, Hayashi A, Kawabata H, Okada T, Takauji S, Sasajima J, Enomoto K, Fujiya M, Oyama K, Ono Y, Sugitani A, Mizukami Y, Okumura T. Prognostic significance of skeletal muscle decrease in unresectable pancreatic cancer: Survival analysis using the Weibull exponential distribution model. Pancreatology. 2021.
  19. Ariyasu R, Uchibori K, Sasaki T, Tsukahara M, Kiyotani K, Yoshida R, Ono Y, Kitazono S, Ninomiya H, Ishikawa Y, Mizukami Y, Yanagitani N, Fujita N, Nishio M, Katayama R. Monitoring epidermal growth factor receptor C797S mutation in Japanese non-small cell lung cancer patients with serial cell-free DNA evaluation using digital droplet PCR. Cancer Sci. 2021;112(6):2371-80.
  20. Wang L, Maejima T, Fukahori S, Shun K, Yoshikawa D, Kono T. Laparoscopic assisted hydrocelectomy of the canal of Nuck: a case report. Surg Case Rep. 2021;7(1):52.
  21. Takauji S, Konishi H, Fujiya M, Ueno N, Tanaka H, Sato H, Isozaki S, Kashima S, Moriichi K, Mizukami Y, Okumura T. Polyphosphate, Derived from Lactobacillus brevis, Modulates the Intestinal Microbiome and Attenuates Acute Pancreatitis. Dig Dis Sci. 2021.
  22. Higashijima J, Tokunaga T, Yoshimoto T, Eto S, Kashihara H, Takasu C, Nishi M, Yoshikawa K, Okitsu H, Ishikawa M, Miyake H, Yagi T, Kono T, Shimada M. A multicenter phase II trial of preoperative chemoradiotherapy with S-1 plus oxaliplatin and bevacizumab for locally advanced rectal cancer. Int J Clin Oncol. 2021;26(5):875-82.
  23. Iseki M, Mizuma M, Aoki Y, Aoki S, Hata T, Takadate T, Kawaguchi K, Masuda K, Ishida M, Ohtsuka H, Nakagawa K, Hayashi H, Morikawa T, Kamei T, Kume K, Kanno A, Masamune A, Omori Y, Ono Y, Mizukami Y, Furukawa T, Unno M. Intracholecystic papillary neoplasm arising in the cystic duct and extending into common bile duct: a case report. Clin J Gastroenterol. 2021;14(2):668-77.
  1. Kono T, Fichera A. Surgical Treatment for Crohn's Disease: A Role of Kono-S Anastomosis in the West. Clinics in Colon and Rectal Surgery. 2020 Nov 14;33(6):335-343.
  2. Miyano K, Eto M, Hitomi S, Matsumoto T, Hasegawa S, Hirano A, Nagabuchi K, Asai N,  Uzu M, Nonaka M, Omiya Y, Kaneko A, Ono K, Fujii H, Higami Y, Kono T, Uezono Y. Author Correction: The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis. Scientific Reports.2020;10:625.
  3. Sadatomi D, Kono T, Mogami S , Fujitsuka N. Weak acids induce PGE 2 production in human oesophageal cells: novel mechanisms underlying GERD symptoms. Scientific Reports.2020.
  4. Maeda K, Katsuno H, Kono T. The Japanese Extracted Herbal Medicine Daikenchuto Increases the Contractile Activity of the Internal Anal Sphincter Muscle in Conscious Dogs. Journal of the Anus, Rectum and Colon. 29 Oct 2020; 4(4):193-200.
  5. Okada T, Mizukami Y, Ono Y, Sato H, Hayashi A, Kawabata H, Koizumi K, Masuda S, Teshima S, Takahashi K, Katanuma A, Omori Y, Iwano H, Yamada M, Yokochi T, Asahara S, Kawakubo K, Kuwatani M, Sakamoto N, Enomoto K, Goto T, Sasajima J, Fujiya M, Ueda J, Matsumoto S, Taniue K, Sugitani A, Karasaki H, Okumura T. Digital PCR-based plasma cell-free DNA mutation analysis for early-stage pancreatic tumor diagnosis and surveillance. Journal of Gastroenterology.2020;55:1183–1193.
  6. Ono Y, Hayashi A, Maeda C, Suzuki M, Wada R, Sato H, Kawabata H, Okada T, Goto T, Karasaki H, Mizukami Y, Okumura T. Time-saving method for directly amplifying and capturing a minimal amount of pamcreatic tumor-derived mutations from fine-needle aspirates using digital PCR. Scientific Reports.2020;10:12332.
  7. Sato H, Sasajima J, Okada T, Hayashi A, Kawabata H, Goto T,Koizumi K, Tamamura N, Tanabe H, Fujiya M, Chiba S, Tanino M, Ono Y, Mizukami Y, Okumura T. Resection for pancreatic cancer metastases contributes to survival: A case report with sequential tumor genotype profiling during the long-term postoperative course.Medicine.2020;99:25(e20564).
  8. Tanabe H, Moriichi K, Takahashi K, Ono Y, Kobayashi Y, Murakami Y, Iwama T, Kunogi T, Sasaki T, Ando K, Ueno N, Kashima S, Takei H, Mizukami Y, Fujiya M, Okumura T. Genetic alteration of colorectal adenoma-carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis. Molecular Genetics & Genomic Medicine. 2020. Sep;8(9):e1348.
  9. Kono T, Fichera A. Surgical Prophylaxis of Crohn Disease Recurrence: "Light at the End of The Tunnel".  Ann Surg. Aug 2020 ; 272(2):218-219
  10. Moriichi K, Tanabe H, Ono Y, Kobayashi Y, Murakami Y, Iwama T, Kunogi T, Sasaki T, Takahashi K, Ando K, Ueno N, Kashima S, Takei H, Mizukami Y, Fujiya M, Okumura T. Serrated adenomas with a BRAF mutation in a young patient with familial adenomatous polyposis. Internationnal Journal of Colorectal Disease. 2020;35:1967–1972.
  11. Tachibana S, Mizukami Y, Ono Y, Sugiyama Y, Okada T, Kitazaki A, Sasajima J, Tominaga M, Sakamoto J, kimura K, Omori Y,Furukawa T, Kimura T, Tanaka S, Nagashima K, Karasaki H, Ohta T, Okumura T. Genetic Tracing of Clonal Expansion and Progression of Pancreatic Ductal Adenocarcinoma: A Case Report and Multi-region Sequencing Analysis. Frontiers in Oncology. 2020. Jun 2;10:728.
  12. Maejima T , Kono T,  Fukahori S, Yoshikawa D,  Karasaki H, Araki Y, Ohta T,  Nagashima K. Evacuatory Dysfunction after Stapled Hemorrhoidopexy: A Case Report of Rectal Pocket Syndrome. J Anus Rectum Colon. 28 Apr 2020 ; 4(2):85-88.
  1. Omori Y, Ono Y, Kobayashi T, Motoi F, Karasaki H, Mizukami Y, Makino N, Ueno Y, Unno M, Furukawa T. How Does Intestinal-type Intraductal Papillary Mucinous Neoplasm Emerge? CDX2 Plays a Critical Role in the Process of Intestinal Differentiation and Progression. Virchows Archiv. 2020 Jul;477(1):21-31.
  2. Aoki Y, Mizuma M, Hata T, Aoki T, Omori Y, Ono Y, Mizukami Y, Unno M, Furukawa T. Intraductal papillary neoplasms of the bile duct are consisted of two distinct types specifically associated with clinicopathological features and molecular phenotypes.  The Journal of Pathology 2020;251(1):38-48.
  3. Kawabata H, Miyazawa Y,Sato H, Okada T, Hayashi A, Iwama T, Fujibayashi S, Goto T, Sasajima J, Takauji S, Fujiya M, Torimoto Y, Tanino M, Omori Y, Ono Y, Karasaki H, Mizukami Y, Okumura T. Genetic analysis of postoperative recurrence of pancreatic cancer potentially owing to needle tract seeding during EUS-FNB. Endoscopy International Open 2019;07:E1768-E1772.
  4. Nagai K, Mizukami Y, Omori Y, Kin T, Yane K, Takahashi K, Ono Y, Sugitani A, Karasaki H, Shinohara T, Furukawa T, Hayashi T, Okumura T, Maguchi H, Katanuma A. Metachronous intraductal papillary mucinous neoplasms disseminate via the pancreatic duct following resection.  Modern Pathology.2019;33:971–980.
  5. Hashimoto S, Furukawa S, Hashimoto A, Tsutaho A, Fukao A, Sakamura Y, Parajuli G, Onodera Y, Otsuka Y, Handa H, Oikawa T, Hata S, Nishikawa Y, Mizukami Y, Kodama Y, Murakami M, Fujiwara T, Hirano S, Sabe H. ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer. PNAS.2019;116 (35):17450-17459.
  6. Kubota K, Mase A, Matsushima H,Fujitsuka N, Yamamoto M, Morine Y, Taketomi A, Kono T, Shimada M. Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern. Neurogastroenterol Motilility. 2019;31(11):e13689.
  7. Takayama Y, Ono Y, Mizukami Y, Itoh H, Nakajima N, Arai H, Tanaka S, Nobusawa S, Yokoo H, Onozato Y. Comparative genome-wide analysis of gastric adenocarcinomas with hyperplastic polyp components. Virchows Archiv. 2019; 475(3):383-389.
  8. Kinoshita K, Katsurada T, Nishida M, Omotehara S, Onishi R, Mabe K, Onodera A, Sato M, Eto K, Suya M, Maemoto A, Hasegawa T, Yamamoto J, Mitsumori D, Yoshii S, Ono K, Sakamoto N. Usefulness of transabdominal ultrasonography for assessing ulcerative colitis: a prospective, multicenter study. J Gastroenterol. 2019 Jun;54(6):521-529.
  9. Sosogi S, Sato R, Wada R, Saito H, Takauji S,Sakamoto J, Kimura K, Karasaki H, Mizukami Y, Ohta T. Clinical course of conservative management for isolated superior mesenteric arterial dissection. European Journal of Radiology Open 6.2019;192-197.
  10. Ogasawara H, Hayasaka M, Maemoto A, Furukawa S, Ito T, Kimura O, Endo T. Stable isotope ratios of carbon, nitrogen and selenium concentration in the scalp hair of Crohn's disease patients who ingested the elemental diet Elental. Rapid Commun Mass Spectrom 2019;33:41-48.


  1. Omori Y, Ono Y, Tanino M, Karasaki H, Yamaguchi H, Furukawa T, Enomoto K, Ueda J, Sumi A, Katayama J, Muraki M, Taniue K, Takahashi K, Ambo Y, Shinohara T,  Nishihara H, Sasajima J, Maguchi H, Mizukami Y, Okumura T, Tanaka S. Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features. Gastroenterology:2019;156:647-661.
  2. Hibi T, Motoya S, Ashida T, Sai S, Sameshima Y, Nakamura S, Maemoto A, Nii M, Sullivan BA, Gasser RA, Suzuki Y. Efficacy and safety of abrilumab, an α4β7 integrin inhibitor, in Japanese patients with moderate-to-severe ulcerative colitis: a phase II study. Intest Res. 2019;17(3):375-386.
  3. Kono T, Shimada M, Nishi M, Morine Y, Yoshikawa K, Katsuno H, Maeda K, Koeda K, Morita S, Watanabe M, Kusano M, Sakamoto J, Saji S, Sokuoka H, Sato Y, Maehara Y, Kanematsu T, Kitajima M. Daikenchuto accelerates the recovery from prolonged postoperative ileus after open abdominal surgery: a subgroup analysis of three randomized controlled trials. Surgery Today.2019;49(8):704-711.
  4. Shimada N, Ohge H, Kono T, Sugitani A, Yano R, Watadani Y, Uemura K, Murakami Y, Sueda Taijiro. Surgical Recurrence at Anastomotic Site After Bowel Resection in Crohn’s Disease : Comparison of Kono-S and End-to-end Anastomosis. Journal of Gastrointestinal Surgery. 2019;23(2):312-319.
  5. Yoshida R, Sasaki T, Umekage Y, Tanno S, Ono Y, Ogata M, Chiba S, Mizukami Y, Ohsaki Y. Highly sensitive detection of ALK resistance mutations in plasma using droplet digital PCR. BMC Cancer. 2018;18(1):1136.
  6. Yamanaka F, Shishido K, Ochiai T, Moriyama N, Yamazaki K, Sugitani A, Tani T,  Tobita K, Mizuno S, Tanaka Y, Murakami M, Takahashi S, Yamazaki S, Saito S. Instantaneous Wave-Free Ratio for the Assessment of Intermediate Coronary Artery Stenosis in Patients With Severe Aortic Valve Stenosis : Comparison With Myocardial Perfusion Scintigraphy. JACC : Cardiovascular Interventions. 2018;11(20):2032-2040.
  7. Okada T, Iwano H, Ono Y, Karasaki H, Sato T, Yamada M, Omori Y, Sato H, Hayashi A, Kawabata H, Goto T, Sasajima J, Takauji S, Nagashima K, Mizukami Y, Okumura T. Utility of “liquid biopsy” using pancreatic juice for early detection of pancreatic cancer. Endoscopy International Open 2018 ;06:E1-E8.
  8. Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, Nomura DK, Haas Wilhelm, Bardeesy N. Mutant GNAS drives pancreatic tumorigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol:2018;811-822.
  9. Goto T, Fujiya M, Konishi H, Sasajima J, Fujibayashi S, Hayashi A, Utsumi T, Sato H, Iwama T, Ijiri M, Sakatani A, Tanaka K, Nomura Y, Ueno N, Kashima S, Moriichi K, Mizukami Y, Kohgo Y, Okumura T. An elevated expression of serum exosomal microRNA-191, -21, -451a of pancreatic neoplasm is considered to be efficient diagnostic marker. BMC Cancer 18:2018;116.
  10. Miyashita T, Kono T, Matsui D, Yamazaki Y, Sadatomi D, Fujitsuka N, Nakanuma S, Okamoto K, Makino I, Kinoshita J, Nakamura K, Oyama K, Tajima H, Takamura H, Ninomiya I, Fushida S, Mukaisho K, Harmon JW, Ohta T. Preventive effect of oral hangeshashinto (TJ-14) on the development of reflux-induced esophageal cancer. Surgery. 2018: S0039-6060(18); 30037-0.
  11. Nishikawa K, Aoyama T, Oba M, Yoshikawa T, Matsuda C, Munemoto Y, Takiguchi N, Tanabe K, Nagata N, Imano M, Oshiro M, Fukushima R, Kataoka M, Morita S, Tsuburaya A, Mishima H, Kono T, Sakamoto J. The clinical impact of Hangeshashinto (TJ-14) in the treatment of chemotherapy-induced oral mucositis in gastric cancer and colorectal cancer: Analyses of pooled data from two phase II randomized clinical trials (HANGESHA-G and HANGESHA-C). Journal of Cancer. 2018: 9(10); 1725-1730.
  12. Wada R, Saito H, Matsuda T, Katada R, Sakamoto J, Ohta T. Transcatheter Arterial Embolization of IgG4-Related Inflammatory CeliacomesentericTrunk Aneurysm. Interventional Radiology 2018; 3: 71-74.
  13. Tajiri H, Motoya S, Kinjo F, Maemoto A, Matsumoto T, Sato N, Yamada H, Nagano M, Susuta Y, Ozaki K, Kondo K, Hibi T. Infliximab for pediatric patients with Crohn's disease: A Phase 3, open-label, uncontrolled, multicenter trial in Japan. PLoS One 2018; 13(8):e0201956. 
  1. Kawachi J, Kashiwagi H, Shimoyama R, Shimoyama N, Fukai R, Miyake K, Egashira H, Sugitani A, Ogino H. Comparison of efficacies of the self-expandable metallic stent versus transanal drainage tube and emergency surgery for malignant left-sided colon obstruction. Asian Journal of Surgery. 2017.
  2. Ono Y, Sugitani A, Karasaki H, Ogata M, Nozaki R, Sasajima J, Yokochi T, Asahara S, Koizumi K, Ando K, Hironaka K, Daito T, Mizukami Y. An improved digital polymerase chain reaction protocol to capture low-copy KRAS mutations in plasma cell-free DNA by resolving 'subsampling' issues. Mol Oncol 11: 2017; 1448-1458.
  3. Nagato T, Ohkuri T, Ohara K, Hirata Y, Kishibe K, Komabayashi Y, Ueda S, Takahara M, Kumai T, Ishibashi K, Kosaka A, Aoki N, Oikawa K, Uno Y, Akiyama N, Sado M, Takei H, Celis E, Harabuchi Y, Kobayashi H. Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy. Cancer Immunol Immunother 66: 2017; 877-890.
  1. Sugiyama Y, Sasajima J, Mizukami Y, Koizumi K, Kawamoto T, Ono Y, Karasaki H, Tanabe H, Fujiya M, Kohgo Y. Gli2 protein expression level is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms. Pol J Pathol 67: 2016; 136-44.
  2. Saha S, Gordan JD, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, Jenkins RL, Rieger-Christ KM, Sullivan TB, Hezel AF, Liss AS, Mizukami Y, Goyal L, Ferrone CR, Zhu AX, Joung JK, Shokat KM, Benes CH, Bardeesy N. Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC-dependence in cholangiocaecinpma.Cancer Discov 6: 2016; 727-39.
  3. Driscoll DR, Karim SA, Sano M, Gay DM, Jacob W, Yu J, Mizukami Y, Gopinathan A, Jodrell DI, Evans J, Bardeesy N, Hall MN, Quattrochi BJ, Klimstra DS, Barry ST, Sansom OW, Lewis BC, Morton JP. mTORC2 signaling is required for pancreatic cancer development and progression. Cancer Res 76: 2016; 6911-6923.
  4. Sugiyama Y, Kawamoto T, Sasajima J, Koizumi K, Karasaki H, Mizukami Y. A rare case of epidermoid cyst in the pancreatic tail invaginated from the splenic hilum:Long-term alteration in imaging findings. Internal Medicine 55: 2016; 3591-3594.
  5. Komabayashi Y, Kishibe K, Nagato T, Ueda S, Takahara M, Harabuchi Y. Circulating Epstein-Barr virus–encoded micro‐RNAs as potential biomarkers for nasal natural killer/T‐cell lymphoma. Hematol Oncol. 2016; DOI: 10.1002/hon.2360.
  6. Yuzawa S, Tanikawa S, Kunibe I, Nishihara H, Nagashima K, Tanaka S. A case of giant cell-rich solitary fibrous tumor in the external auditory canal. Pathol Int 66: 701-705 2016; DOI:10.1111/pin.12470.
  7. Sasajima J, Fujita M, Uehara J, Goto T, Fujibayashi S, Koizumi K, Mizukami Y, Yamamoto A, Okumuta T. Pancreatic metastasis of angiosarcoma(Stewart-Treves syndrome)diagnosed using endoscopic ultrasound-guided fine needle aspiration: A case report. Medicine 95. 2016; e4316.
  8. Nozaki R, Kono T, Bochimoto H, Watanabe T, Oketani K, Sakamaki Y, Okubo N, Nakagawa K, Takeda H. Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells. Oncotarget. 2016Oct 25;7(43):70437-70446.
  9. Kono T, Fichera A, Maeda K, Sakai Y, Ohge H, Krane M, Katsuno H, Fujiya M. Kono-S anastomosis for surgical prophylaxis of anastomotic recurrence in Crohn's disease: an international multicenter study. J Gastrointest Surg 2016; 20(4): 783-790.
  10. Tsuchiya K, Kubota K, Ohbuchi K, Kaneko A, Ohno N, Mase A, Matsushima H, Yamamoto M, Miyano K, Uezono Y, Kono T. Transient receptor potential ankyrin 1 (TRPA1) agonists improve intestinal transit in a murine model of postoperative ileus. Neurogastroenterol Motil .2016 Dec;28(12):1792-1805..
  11. Maejima T, Kono T, Orii F, Maemoto A, Furukawa S, Liming W, Kasai S, Fukahori S, Mukai N, Yoshikawa D, Karasaki H, Saito H, Nagashima K. Anal canal adenocarcinoma in a patient with long-standing Crohn’s disease arising from rectal mucosa that migrated from a previously treated rectovaginal fistula. Am J Case Rep 2016; 17: 448-53.
  12. Hasebe T, Ueno N, Musch M, Nadimpalli A, Kaneko A, Kaifuchi N, Watanabe J, Yamamoto M, Inaba Y, Kono T, Fujiya M, Kohgo Y, Chang E. Daikenchuto (TU-100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K Pharmacology. Research & Perspectives 2016; 4(1): e00215.
  13. Yada K, Ishibashi H, Mori H, Morine Y, Zhu C, Feng R, Kono T, Shimada M. The Kampo medicine "Daikenchuto (TU-100)" prevents bacterial translocation and hepatic fibrosis in biliary atresia rat model. Surgery 2016; 159(6): 1600-11.
  14. Matsuzaka S, Karasaki H, Ono Y, Ogata M, Oikawa K, Tamakawa S, Chiba S, Muraki M, Yokochi T, Funakoshi H, Kono T, Nagashima K, Mizukami Y. Tracking the Clonal Evolution of Adenosquamous Carcinoma, a Rare Variant of Intraductal Papillary Mucinous Neoplasm of the Pancreas. Pancreas 2016; 45(6): 915-8.
  15. Shinsuke K, Orii F, Maemoto A, Ashida T. Reversible Posterior Leukoencephalopathy Syndrime Associated with Treatment for Acute Exacerbation of Ulcerative Colitis.Intern Med 2016;55:473-477.
  1. Imai K, Karasaki H, Ono Y, Sasajima J, Chiba S, Funakoshi H, Muraki M, Hanaoka H, Furukawa T, Furukawa H, Kono T, Nagashima K, Mizukami Y. Metachronous pancreatic cancer originating from disseminated founder pancreatic intraductal neoplasias (PanINs): Study using human specimen to reconsider mode of pancreatic cancer progression and recurrence. J Pathol Clin Res 2015; 1: 76-82.
  2. Makino Y, Tsuda M, Ohba Y, Nishihara H, Sawa H, Nagashima K, Tanaka S. Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation. Cell Commun Signal 2015; 13: 55.
  3. Ito T, Sato K, Oikawa A, Sugio H, Asanome T, Ozaki Y, Nakamura H, Tanaka S, Tsuda M, Nagashima K. Clinocopathological study of pilomyxoid-spectrum astrocytoma. An analysis of the BRAF gene. Report of two cases. No Shinkei Gekagaku 2015; 43: 825-33.
  4. Kono T, Suzuki Y, Mizuno K, Miyagi C, Omiya Y, Sekine H, Mizuhara Y, Miyano K, Uezono Y. Preventive effect of oral goshajinkigan on chronic oxaliplatin-induced hypoesthesia in rats. Scientific Reports 2015; 5: 16078.
  5. Matsuda C, Munemoto Y, Mishima H, Nagata N, Oshiro M, Kataoka M, Sakamoto J, Aoyama T, Morita S, Kono T. Double-blind, placebo-controlled, randomized phase II study of TJ-14 (Hangeshashinto) for infusional fluorinated-pyrimidine-based colorectal cancer chemotherapy-induced oral mucositis. Cancer Chemother Pharmacol 2015; 76(1): 97-103.
  6. Sadakane C, Watanabe J, Fukutake M, Nisimura H, Maemura K, Kase Y, Kono T. Pharmacokinetic Profiles of Active Components After Oral Administration of a Kampo Medicine, Shakuyakukanzoto, to Healthy Adult Japanese Volunteers. J Pharm Sci 2015; 104(11): 3952-9.
  7. Katsuno H, Maeda K, Kaiho T, Kunieda K, Funahashi K, Sakamoto J, Kono T, Hasegawa H, Furukawa Y, Imazu Y, Morita S, Watanabe M. Clinical efficacy of Daikenchuto for gastrointestinal dysfunction following colon surgery: a randomized, double-blind, multicenter, placebo-controlled study (JFMC39-0902). Jpn J Clin Oncol 2015; 45(7): 650-6.
  8. Watanabe J, Kaifuchi N, Kushida H, Matsumoto T, Fukutake M, Nishiyama M, Yamamoto M, Kono T. Intestinal, portal, and peripheral profiles of daikenchuto (TU-100)'s active ingredients after oral administration. Pharmacol Res Perspect 2015; 3(5): e00165.
  9. Suzuki T, Kono T, Bochimoto H, Hira Y, Watanabe T, Furukawa H. An injured tissueaffects the opposite intact peritoneum during postoperative adhesion formation. Scientific Reports 2015; 5: 7668.
  10. Katsuno H, Maeda K, Hanai T, Masumori K, Koide Y, Kono T. Novel antimesentericfunctional end-to-end handsewn (Kono-S) anastomoses for Crohn's disease: a reportof surgical procedure and short-term outcomes. Dig Surg 2015; 32(1): 39-44.
  11. Kubota K, Ohtake N, Ohbuchi K, Mase A, Imamura S, Sudo Y, Miyano K, Yamamoto M,Kono T, Uezono Y. Hydroxy-α sanshool induces colonic motor activity in rat proximalcolon: a possible involvement of KCNK9. Am J Physiol Gastrointest Liver Physiol 2015;308(7): G579-90.
  12. Oki E, Emi Y, Kojima H, Higashijima J, Kato T, Miyake Y, Kon M, Ogata Y, Takahashi K,Ishida H, Saeki H, Sakaguchi Y, Yamanaka T, Kono T, Tomita N, Baba H, Shirabe K,Kakeji Y, Maehara Y. Preventive effect of Goshajinkigan on peripheral neurotoxicity ofFOLFOX therapy (GENIUS trial): a placebo-controlled, double-blind, randomized phaseIII study. Int J Clin Oncol 2015; 20(4): 767-75.
  1. Nishimura J, Yamamoto M, Hayashi S, Ohyashiki K, Ando K, Brodsky AL, Noji H,Kitamura K, Eto T, Takahashi T, Masuko M, Matsumoto T, Wano Y, Shichishima T,Shibayama H, Hase M, Li L, Johnson K, Lazarowski A, Tamburini P, Inazawa J, KinoshitaT, Kanakura Y. Genetic variants in C5 and poor response to eculizumab. N Engl J Med2014; 370(7): 632-9.
  2. Takahashi N, Miura M, Kuroki J, Mitani K, Kitabayashi A, Sasaki O, Kimura H, Imai K,Tsukamoto N, Noji H, Kondo T, Motegi M, Kato Y, Mita M, Saito H, Yoshida C, TorimotoY, Kimura T, Wano Y, Nomura J, Yamamoto S, Mayama K, Honma R, Sugawara T, SatoS, Shinagawa A, Abumiya M, Niioka T, Harigae H, Sawada K. Multicenter phase IIclinical trial of nilotinib for patients with imatinib-resistant or -intolerant chronicmyeloid leukemia from the East Japan CML study group evaluation of molecularresponse and the efficacy and safety of nilotinib. Biomark Res 2014; 2(1): 6-14.
  3. Hibi T, Sakuraba A, Watanabe M, Motoya S, Ito H, Sato N, Yoshinari T, Motegi K,Kinouchi Y, Takazoe M, Suzuki Y, Matsumoto T, Kawakami K, Matsumoto T, Hirata I,Tanaka S, Ashida T, Matusi T. C-reactive protein is an indicator of serum infliximablevel in predicting loss of response in patients with Crohn's disease. J Gastroenterol2014; 49(2): 254-62.
  4. Khan MR, Yazawa T, Anisuzzaman AS, Semba S, Ma Y, Uwada J, Hayashi H, Suzuki Y,Ikeuchi H, Uchino M, Maemoto A, Muramatsu I, Taniguchi T. Activation of focaladhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution ofintestinal barrier function after epihelial injury. Biochim Biophys Acta 2014; 1842(4):635-645.
  5. Takahashi K, Tsuda M, Kanno H, Murata J, Mahabir R, Ishida Y, Kimura T, Tanino M,Nishihara H, Nagashima K, Tanaka S. Differential diagnosis of small cell glioblastomaand anaplastic oligodendroglioma: a case report of an elderly man. Brain TumorPathol 2014; 31: 118‒123.
  6. Kono T, Takeda H, Shimada M, Kase Y, Uezono Y. Novel therapeutics for adverseeffects of antitumor therapy: the promise of multicomponent, traditional Japaneseherbal remedies. J Carcinog Mutagen 2014; S8-007.
  7. Kono T, Kaneko A, Matsumoto C, Miyagi C, Ohbuchi K, Mizuhara Y, Miyano K, UezonoY. Multitargeted Effects of Hangeshashinto for Treatment of Chemotherapy- InducedOral Mucositis on Inducible Prostaglandin E2 Production in Human Oral Keratinocytes.Integr Cancer Ther 2014; 13(5): 435-445.
  8. Kono T, Fichera A. Kono-S anastomosis for Crohn’ s disease. Colorectal Disease 2014;16(10): 833.
  9. Shimada M, Morine Y, Nagano H, Hatano E, Kaiho T, Miyazaki M, Kono T, Kamiyama T,Morita S, Sakamoto J, Kusano M, Saji S, Kanematsu T, Kitajima M. Effect of TU-100, atraditional Japanese medicine, administered after Hepatic Resection in Patients withLiver Cancer: a multi-center, randomized, double-blind, placebo-controlled phase IItrial (JFMC40-1001). Int J Clin Oncol 2014; 73(5): 1047-1054.
  10. Ueno N, Hasebe T, Kaneko A, Yamamoto M, Fujiya M, Kohgo Y, Kono T, Wang CZ, YuanCS, Bissonnette M, Chang EB, Musch MW. TU-100 (daikenchuto) and ginger ameliorateanti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independenteffects involving Akt and NF-κB suppression. PLoS ONE 2014; 9(5): e97456.
  11. Mizuno K, Kono T, Suzuki Y, Miyagi C, Omiya Y, Miyano K, Kase Y, Uezono Y.Goshajinkigan, a traditional Japanese medicine, prevents oxaliplatin-induced acuteperipheral neuropathy by suppressing functional alteration of TRP channels in rat. JPharmacol Sci 2014; 125(1): 91-98.
  12. Aoyama T, Nishikawa K, Takiguchi N, Tanabe K, Imano M, Fukushima R, Sakamoto J,Oba MS, Morita S, Kono T, Tsuburaya A. Double-blind, placebo-controlled, randomizedphase II study of TJ-14 (hangeshashinto) for gastric cancer chemotherapy-inducedoral mucositis. Cancer Chemother Pharmacol 2014; 73(5): 1047-1054.
  13. Watanabe K, Karasaki H, Mizukami Y, Kawamoto T, Kono T, Imai K, Einama T, TaniguchiM, Kohgo Y, Furukawa H. Cyst infection of intraductal papillary mucinous neoplasmsof the pancreas: management of a rare complication: report of 2 cases. Pancreas 2014;43(3): 478-81.
  14. Furukori M, Imai K, Karasaki H, Watanabe K, Oikawa K, Miyokawa N, Taniguchi M,Furukawa H. Clinicopathological features of small nonfunctioning pancreaticneuroendocrine tumors. World J Gastroenterol 2014; 20(47): 17949-54.
  15. Einama T, Uchida K, Taniguchi M, Ota Y, Watanabe K, Imai K, Karasaki H, Chiba A,Oikawa K, Miyokawa N, Furukawa H. Successful curative resection of gallbladdercancer following S-1 chemotherapy: A case report and review of the literature. OncolLett 2014; 8(6): 2443-2447.
  16. Takeshita S, Asano H, Hata T, Hibi K, Ikari Y, Kan Y, Katsuki T, Kawasaki T, Masutani M,Matsumura T, Premchand RK, Rao SP, Suzuki T, Takahashi A, Takeda R, Tanaka S,Yamazaki S, Yin WH, Yoshimachi F, Saito S; NAUSICA Trial Investigators. Comparison offrequency of radial artery occlusion after 4Fr versus 6Fr transradial coronaryintervention (from the Novel Angioplasty USIng Coronary Accessor Trial). Am J Cardiol2014; 113(12):1986-9.
  17. Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, BardeesyN, Chung DC. Germline mutations in oncogene-induced senescence pathways areassociated with multiple sessile serrated adenomas. Gastroenterology 2014; 146:520-9.
  1. Khan MR, Anisuzzaman AS, Semba S, Ma Y, Uwada J, Hayahi H, Suzuki Y, Takano T,Ikeuchi H, Uchino M, Maemoto A, Ushikubi F, Muramatsu I, Taniguchi T. M1 is a majorsubtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells. JGastroenterol 2013; 48(8): 885-96.
  2. Khan MR, Yazawa T, Anisuzzaman AS, Semba S, Ma Y, Uwada J, Hayashi H, Suzuki Y,Ikeuchi H, Uchino M, Maemoto A, Muramatsu I, Taniguchi T. Activation of focaladhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution ofintestinal barrier function after epihelial injury. Biochim Biophys Acta 2013; 1842(4):635-645.
  3. Kawamoto T, Sasajima J, Sugiyama Y, Nakamura K, Tanabe H, Fujiya M, Nata T, Iuchi Y,Ashida T, Torimoto Y, Mizukami Y, Kohgo Y. Ex vivo activation of angiogenic propertyin human peripheral blood-derived monocytes by thrombopoietin. Int J Hematol2013; 98(4): 417-29.
  4. Takahashi K, Orba Y, Kimura T, Wang L, Kohsaka S, Tsuda M, Tanino M, Nishhara H,Nagashima K, Sawa H, Tanaka S. Relationship between Methyl CpG binding protein 2and JC virus proteins. Jpn J Infect Dis 2013; 66: 126-132.
  5. Kanno H, Tanino M, Watanabe K, Ozaki Y, Itoh T, Kimura T, Nishihara H, Itoh T, Narita T,Nagashima K, Tanaka S. Intracranial mass-forming lesion associated with duralthickening and hypophysitis. Neuropathology 2013; 33: 213-216.
  6. Kono T, Kaneko A, Omiya Y, Ohbuchi K, Ohno N, Yamamoto M. Epithelial transientreceptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin up-regulates bloodflow in rat small intestine. Am J Physiol Gastrointest Liver Physiol 2013; 304: 428-36.
  7. Kono T, Hata T, Morita S, Munemoto Y, Matsui T, Kojima H, Takemoto H, Fukunaga M,Nagata N, Shimada M, Sakamoto J, Mishima H. Goshajinkigan OxaliplatinNeurotoxicity Evaluation (GONE): a phase 2, multicenter, randomized, double-blind,placebo-controlled trial of goshajinkigan to prevent oxaliplatin-induced neuropathy.Cancer Chemotherapy and Pharmacology 2013; 72(6): 1283-1290.
  8. Munekage M, Ichikawa K, Kitagawa H, Uehara H, Watanabe J, Kono T, Hanazaki K.Population Pharmacokinetic Analysis of Daikenchuto, a Traditional Japanese Medicine(Kampo) in Japanese and US Health Volunteers. Drug Metab Dispos.2013; 41:1256-1263.
  9. Kaneko A, Kono T, Miura N, Tsuchiya N, Yamamoto M. Preventive effect of TU-100 on atype-2 model of colitis in mice: Possible involvement of enhancing adrenomedullin inintestinal epithelial cells. Gastroenterology Research and Practice 2013: 384057.
  10. Sakatani A, Fujiya M, Ito T, Inaba Y, Ueno N, Kashima S, Tominaga M, Moriichi K,Okamoto K, Tanabe H, Ikuta K, Ohtake T, Kono T, Furukawa H, Ashida T, Kohgo Y.Infliximab extends the duration until the first surgery in patients with Crohn’ sdisease. BioMed Research International 2013: 879491.
  11. Abe T, Kono T, Hachiro Y, Kunimoto M, Furukawa H. Risk factors for internal analsphincter dysfunction in Japanese adults. Open J Gastroenterology 2013; 3(1): 25-34.
  12. Aburakawa Y, Kawabe J, Okada M, Yamauchi A, Asanome A, Kabara M, Matsuki M,Takehara N, Nakagawa N, Okumura S, Minami Y, Mizukami Y, Yuhki K, Ushikubi F,Hasebe N. Prostacyclin stimulated integrin-dependent angiogenic effects ofendothelial progenitor cells and mediated potent circulation recovery in ischemichind limb model. Circ J 2013; 77(4): 1053-62.
  1. Yoshida A, Zokumasu K, Wano Y, Yamauchi T, Imamura S, Takagi K, Kishi S, Urasaki Y,Tohyama K, Ueda T. Marked upregulation of Survivin and Aurora-B kinase isassociated with disease progression in the myelodysplastic syndromes.Haematologica 2012; 97(9): 1372-9.
  2. Ito T, Tanabe H, Ayabe T, Ishikawa C, Inaba Y, Maemoto A, Kono T, Ashida T, Fujiya M,Kohgo Y. Paneth cells regulate both chemotaxis of immature dendritic cells andcytokineproduction from epithelial cells. Tohoku J Exp Med 2012; 227(1): 39-48.
  3. Saito M, Nishihara H, Tanino M, Kimura T, Matsuno Y, Nagashima K, Shimizu M, TanakaS. Pancreatic carcinoma with prominent mucin production: A clinicopathologic andimmunohistochemical study of 9 cases. Open J Pathol 2012; 2: 15-20.
  4. Kono T, Asama T, Chisato N, Ebisawa Y, Okayama T, Imai K, Karasaki H, Furukawa H,Yoneda M. Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats.Life Sciences 2012; 90: 122-130.
  5. Kono T, Satomi M, Suno M, Kimura N, Yamazaki H, Furukawa H, Matsubara K.Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acutehypersensitivity to cold sensation. Brain and Behavior 2012; 2(1): 68-73.
  6. Fischera A, Zoccali M, Kono T. Antimesenteric functional end-to-end handsewn(Kono-S) anastomosis. J Gastrointestinal Surgery 2012; 16(7): 1412-1416.
  7. Nozakia, R, Tamura S, Ito A, Moriyama T, Yamaguchi K, Kono T. A rapid method toisolate soluble royal jelly proteins. Food Chemistry 2012; 134(4): 2332-7.
  8. Ota Y, Aso K, Watanabe K, Einama T, Imai K, Karasaki H, Sudo R, Tamaki Y, Okada M,Tokusashi Y, Kono T, Miyokawa N, Haneda M, Taniguchi M, Furukawa H. Hepaticschwannoma: imaging findings on CT, MRI and contrast-enhanced Ultrasonography.World J Gastroenterol 2012; 18(35): 4967-72.
  9. Hachinohe D, Saito S, Tani T, Yamazaki S. Mother-and-child technique using 4-Fr innercatheter for stent delivery during provisional stenting. Cardiovasc Interv Ther 2012; 27(2): 105-9.
  10. Stone PH, Saito S, Takahashi S, Makita Y, Nakamura S, Kawasaki T, Takahashi A, KatsukiT, Nakamura S, Namiki A, Hirohata A, Matsumura T, Yamazaki S, Yokoi H, Tanaka S,Otsuji S, Yoshimachi F, Honye J, Harwood D, Reitman M, Coskun AU, Papafaklis MI,Feldman CL. Prediction of progression of coronary artery disease and clinicaloutcomes using vascular profiling of endothelial shear stress and arterial laquecharacteristics: the PREDICTION Study. Circulation 2012; 126(2): 172-81.
  11. Hachinohe D, Jeong MH, Saito S, et al. Clinical Impact of Thrombus Aspiration duringPrimary Percutaneous Coronary Intervention: Results from Korea Acute MyocardialInfarction Registry. J Cardiol 2012; 59(3): 249-57.
  12. Hachinohe D, Jeong MH, Saito S, et al. Comparison of Different Types of Drug-ElutingStents in Acute Myocardial Infarction Patients with Chronic Kidney Disease. Korean JIntern Med 2012; 27(4): 397-406.
  13. Moriichi K, Fujiya M, Sato R, Nata T, Nomura Y, Ueno N, Ishikawa C, Inaba Y, Ito T,Okamoto K, Tanabe H, Mizukami Y, Watari J, Saitoh Y, Kohgo Y. Autofluorescenceimaging and the quantitative intensity of fluorescence for evaluating the dysplasticgrade of colonic neoplasms. Int J Colorectal Dis 2012; 27: 325-30.
  14. Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H,Mizukami Y, Chang EB, Kohgo Y. Competence and sporulation factor derived fromBacillus subtilis improves epithelial cell injury in intestinal inflammation viaimmunomodulation and cytoprotection. Int J Colorectal Dis 2012; 27: 1039-1046.
  15. Duerr EM, Mizukami Y, Moriichi K, Gala M, Jo WS, Kikuchi H, Xavier RJ, Chung DC.Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines. Am J PhysiolGastrointest Liver Physiol 2012; 302(10): G1223-30.
  16. Motomura W, Yoshizaki T, Takahashi N, Kumei S, Mizukami Y, Jang SJ, Kohgo Y.Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response toa high-fat diet and free fatty acids. J Clin Biochem Nutr 2012; 51: 163-9.
  17. Muto M, Sato R, Fujiya M, Tanaka K, Serikawa S, Hayashi A, Konno Y, Sakamoto J,Nishikawa T, Oikawa K, Ueno N, Ikuta K, Mizukami Y, Tanno S, Watari J, Kohgo Y.Pseudo-diverticular formation due to a cytomegalovirus infection in the colorectum.Dig Endosc 2012; 24: 193.
  18. Moriichi K, Fujiya M, Sato R, Watari J, Nomura Y, Nata T, Ueno N, Maeda S, Kashima S,Itabashi K, Ishikawa C, Inaba Y, Ito T, Okamoto K, Tanabe H, Mizukami Y, Saitoh Y,Kohgo Y. Back-to-back comparison of auto-fluorescence imaging (AFI) versus highresolution white light colonoscopy for adenoma detection. BMC Gastroenterol 2012;12: 75.
  1. Kono T, Ashida T, Ebisawa Y, Chisato N, Okamoto K, Katsuno H, Maeda K, Fujiya M. A new antimesenteric functional end to end hand-sewn anastomosis. Surgical prevention of anastomotic recurrence in Crohn's disease. Diseases of the Colon & Rectum 2011; 54(5): 586-592.
  2. Kono T, Kashiwade Y, Asama T, Chisato N, Ebisawa Y, Yoneda M, Kasai S.  Preventive effect of urinary trypsin inhibitor on the development of liver fibrosis in mice. Exp Biol Med (Maywood) 2011; 236(11): 1314-21.
  3. Kono T, Omiya Y, Hira Y, Kaneko A, Chiba S, Suzuki T, Noguchi M, Watanabe T. Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat model. J Gastroenterol 2011; 46(10): 1187-96.
  4. Kono T, Mamiya N, Chisato N, Ebisawa Y, Yamazaki H, Watari J, Yamamoto Y, Suzuki S, Asama T, Kamiya K Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer. Evidence Based Complementary and Alternative Medicine 2011:418481.
  5. Kono T, Satomi M, Asama T, Ebisawa Y, Chisato N, Suno M, Karasaki H, Furukawa H, Matsubara K. Cetuximab-induced hypomagnesaemia aggravates peripheral sensory neurotoxicity caused by oxaliplatin. Journal of Gastrointestinal Oncology 2010; 1(2): 97-101.
  6. Kono T, Satomi M, Chisato N, Ebisawa Y, Suno M, Asama T, Karasaki H, Matsubara K, Furukawa H. Topical application of hangeshashinto (TJ-14) in the treatment of chemotherapy-induced oral mucositis. World Journal of Oncology 2010; 1(6): 232-235.
  7. Kono T, Kaneko A, Hira Y, Suzuki T, Chisato N, Ohtake N, Miura N, Watanbe T. Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn's disease mouse model. Journal of Crohn’s and Colitis 2010; 4: 161-170.
  8. Sasajima J, Mizukami Y, Sugiyama Y, Nakamura K, Kawamoto T, Koizumi K, Fujii R, Motomura W, Sato K, Suzuki Y, Tanno S, Fujiya M, Sasaki K, Shimizu N, Karasaki H, Kono T, Kawabe JI, Ii M, Yoshiara H, Kamiyama N, Ashida T, Bardeesy N, Chung DC, Kohgo Y. Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors. Cancer Research 70; 2010:6283-92.
  9. Kono T, Mishima H, Shimada M, Morita S, Sakamoto J; for the GONE investigators. Preventive Effect of Goshajinkigan on Peripheral Neurotoxicity of FOLFOX Therapy: A Placebo-controlled Double-blind Randomized Phase II Study (the GONE Study). Jpn J Clin Oncol 2009; 39(12): 847-9.
  10. Kono T, Kanematsu T, Kitajima M. Exodus of Kampo, traditional Japanese medicine, from the complementary and alternative medicines: is it time yet? Surgery 2009; 146(5): 837-40.
  11. Kono T, Koseki T, Chiba S, Ebisawa Y, Chisato N, Iwamoto J, Kasai S. Colonic Vascular Conductance Increased by Daikenchuto via Calcitonin Gene-Related Peptide and Receptor-Activity Modifying Protein 1. J Surg Res 2008; 150: 78-84.
  12. Mizukami Y, Kohgo Y, Chung DC. HIF-1 independent pathways in tumor angiogenesis (Review). Clinical Cancer Research 13;2007:5670-5674.
  13. Mizukami Y, Fujiki K, Duerr EM, Gala M, Jo SW, Zhang XB, Chung DC. Hypoxic regulation of vascular endothelial growth factor through the induction of PI3K/Rho/ROCK and c-Myc. Journal of Biological Chemistry 281; 2006:13957-63.
  14. Kono T, Ebisawa Y, Tomita I, Chisato N, Kamiya K, Asama T, Ayabe T, Kohgo Y, Kasai S. Phase II study of irinotecan, leucovorin, 5-fluorouracil, and tegafur/uracil for metastatic colorectal cancer (MCRC). J Chemotherpy 2005; 17(2): 224-227.
  15. Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang XB, Zimmer MA, Iliopoulos O, Zukerberg LR, Kohgo Y, Lynch MP, Rueda BR, Chung DC. Induction of interleukin-8 preserves the angiogenic response in HIF-1α deficient colon cancer cells. Nature Medicine 11:2005:992-997.
  16. Li J, Mizukami Y, Zhang XB, Jo SW, Chung DC. Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3β. Gastroenterology 128;2005:1907-1918.
  17. Kono T, Chisato N, Ebisawa Y, Asama T, Sugawara M, Yoneda M, Ayabe T, Kohgo Y, Kasai S. Takahashi T. Impaired nitric oxide production of the myenteric plexus in colitis detected by a new bio-imaging system. J Surg Res 2004; 117(2): 329-338.
  18. Kono T, Tomita I, Chisato N, Matsuda M, Kakisaka A, Kasai S. Successful Low-Dose Chemotherapy Using Vinblastine and Methotrexate for the Treatment of an Ileoanal Pouch Mesenteric Desmoid Tumor: Report of a Case. Disease colon and rectum 2004; 47(2): 246-249.
  19. Kono T, Kotani H, Asama T, Mamiya N, Ohara K, Yoneda M, Iwamoto J, Kasai S. Protective effect of pretreatment with low-dose lipopolysaccharide on D-galactosamine-induced acute liver failure. Int J Colorectal Dis 2002; 17(2): 98-103.
  20. Kono T, Kotani H, Asama T, Mamiya N, Ohara K, Yoneda M, Iwamoto J, Kasai S. Adaptive cytoprotection against acetic acid-induced colonic injury in rat. Int J Colorectal Dis 2001; 16(6): 384-390.
  21. Kono T, Nishida M, Inagaki N, Tanaka Y, Yoneda M, Kasai S. Development and characterization of 1C6-203, a new monoclonal antibody specific to the human thymidine phosphorylase. J Histochem Cytochem 2001; 49(1): 131-138.
  22. Kono T, Nomura M, Kasai S, Kohgo Y. Effect of ecabet sodium enema on mild to moderate active ulcerative proctosigmoiditis: An open study. Am J Gastroenterol 2001; 96(3): 793-797.
  23. Kono T, Yoneda M, Ohara K, Ayabe T, Chisato N, Kohgo Y, Kasai S, Terano A, Tach Y. Adaptive cytoprotection against acetic acid-induced colonic injury in rats. Int J Colorectal Dis 2001; 16(6): 384-390.
  24. Kono T, Yamamoto Y, et al. Adenosquamous carcinoma with endocrine cell differentiation of the rectum: report of a case. Disease Colon Rectum 1999; 42(8): 1089-92.
  25. Kono T, Miyata M, et al. Pelvic nerve grafts restore bladder function in denervated rats. Surgery 1998; 123(6): 672-8.